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Prednisolone: Key Information

Characteristic Description
Active Ingredient Prednisolone
Available Dosages 5 mg, 10 mg, 20 mg
Form Tablet, Liquid
Indications Anti-inflammatory, Immunosuppressive
Prescription Requirement Yes
More on Prednisolone

Pharmacokinetics

Prednisolone exhibits efficient absorption upon oral administration. The liver processes it into its active form. It exhibits a bioavailability of 70-90%. Distribution occurs rapidly across tissues, with high concentrations in the liver and intestines. The half-life ranges between 2 to 4 hours. Excretion primarily involves renal pathways, with metabolites leaving through urine.

Prednisolone’s metabolism involves reduction and conjugation. The peak plasma concentration typically occurs within 1-2 hours post-dose. Protein binding stands at approximately 70%. Tissue distribution depends on lipophilicity. Its mechanism involves binding to cytoplasmic receptors, modifying gene transcription, and modulating immune responses.

Dosage Information

Prednisolone 20 mg is commonly prescribed for moderate inflammatory conditions. Initial doses may vary based on severity. Maintenance involves tapering to the lowest effective dose. In pediatric cases, dosing requires adjustment based on weight.

Patients must adhere to prescribed dosages to mitigate adverse effects. Long-term use necessitates periodic evaluation of necessity. In certain conditions, alternate-day dosing may prove beneficial. Physicians often assess treatment efficacy through clinical markers.

FDA-Approved Indications

Prednisolone is FDA-approved for a spectrum of inflammatory and autoimmune disorders. Conditions include asthma, rheumatoid arthritis, and lupus. It serves as an essential therapy in managing acute exacerbations. Ophthalmic formulations target ocular inflammation.

Indications extend to organ transplant rejection prevention. It remains integral in chemotherapy regimens to alleviate inflammatory side effects. Prednisolone 20 mg finds frequent use in managing chronic obstructive pulmonary disease exacerbations.

Cautions with Other Medicines

Prednisolone interacts with numerous medications. Concomitant use with NSAIDs may elevate gastrointestinal ulcer risk. Anticoagulants can experience altered effects. Diabetes medications may require adjustments due to hyperglycemic potential.

Combining with certain vaccines can attenuate immunogenic responses. Co-administration with anticonvulsants might necessitate dose alterations. Antifungal agents may alter prednisolone’s metabolism. Vigilant monitoring is crucial for polypharmacy patients.

Side Effects

Common side effects include fluid retention and hypertension. Long-term use increases osteoporosis risk. Other effects encompass weight gain and mood alterations. Hyperglycemia represents a concern, particularly in diabetic patients.

Eye-related side effects include increased intraocular pressure. Muscle weakness can occur with prolonged therapy. Patients may experience heightened infection susceptibility. Regular assessments help manage and mitigate these effects.

Is Non-prescription Prednisolone Available?

Prednisolone is available solely by prescription. Its potent effects necessitate medical supervision. Non-prescription availability might lead to inappropriate use.

Healthcare providers tailor regimens to individual patient needs. Self-medication poses significant health risks. Prescription ensures proper monitoring and dose adjustments.

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